News

Say goodbye to jet lag

Say goodbye to jet lag

Photo: clipart.com

LONDON (Reuters) – Scientists have found a genetic mechanism in mice that hampers their body clock’s ability to adjust to changes in patterns of light and dark, and say their results could someday lead to the development of drugs to combat jet lag.

Researchers from Britain’s Oxford University and from the Swiss drug firm Roche used mice to analyze patterns of genes in an area of the brain called the suprachiasmatic nuclei (SCN) – which in mammals pulls every cell in the body into the same biological rhythm.

They found that one molecule, called SIK1, is key to how the mice responded to changes in light cycles.

When the scientists blocked the activity of SIK1, the mice recovered faster from disturbances in their daily light and dark cycle that had been designed to induce a form of mouse jet lag.

If the corresponding mechanism can be found and similarly blocked in humans, jet lag may become a thing of the past, the researchers said in their study, published online in the journal Cell on Thursday.

“We’re still several years away from a cure for jet lag, but understanding the mechanisms that generate and regulate our circadian clock gives us targets to develop drugs to help bring our bodies in tune with the solar cycle,” said Russell Foster, director of Oxford’s sleep and circadian neuroscience institute.

He said such drugs could also have broader potential value, including for people with mental illnesses where sleep disturbances are common.

Recent News

in Entertainment

Third ‘Night at the Museum’ marks final film for Williams, Rooney

nightatthemuseum

The credits for "Secret of the Tomb," which opens Friday, read "In loving memory of Mickey Rooney," and "For Robin Williams - the magic never ends."

in Music

Noel Gallagher embarrassed daughter in front of Harry Styles

Noel Gallagher and Anais Gallagher at Arthur - UK film premiere held at the O2 Arena - Arrivals.
London, England - 19.04.11

Noel Gallagher left his teenage daughter mortified by embarrassing her in front of One Direction heart-throb Harry Styles.

in Music

Gene Simmons credits mother for drug-free life

Gene Simmons speaks onstage during the "4th and Loud" portion of the AMC 2014 Summer TCA on Friday, July 11, 2014, in Beverly Hills, Calif.

The Kiss frontman insists he has never been drunk or gotten high because he always worried about his mom's reaction.

in Music

Joan Jett to open for The Who’s 50th anniversary tour

joan

The "My Generation" hitmakers are set to bring their The Who Hits 50! tour to North America.

in Entertainment

Chris Pratt thought ‘Guardians’ would be a box office flop

Guardians Of The Galaxy

The "Parks and Rec" star was very, very wrong.